500,000 Britons’ Genomes Will Be Public by 2020, Transforming Drug Research

In an effort to vault genetics into a new era of big data, six drug companies say they will decode the genes of half a million Brits and then make the data public—all by 2020.
The plan will turn the UK Biobank, the source of the DNA samples, into the world’s single biggest concentration of genetic and health data anywhere, giving scientists and drug companies a powerful tool for understanding diseases.
The UK Biobank is already a treasure trove: a public database containing carefully assembled medical records, test results, and even psychological assessments the country has collected from 500,000 volunteers.
Its first big release of data last July—anonymized to protect people’s identities—electrified scientists. With a click of a mouse, they can inspect the genetic basis of everything from diabetes to TV-watching habits.
But the genetic data it contains are limited. Now the sequencing consortium plans to decode all 20,000 or so genes of each volunteer. Such “exome” sequencing falls short of decoding the complete genome, but it captures the parts most important to drug makers—the genetic sequences that code for proteins, the building blocks of life and, when they go awry, the cause of most health problems.
Adding those gene sequences would “increase [the Biobank’s] value 100 times for drug development, and 10 to 100 times for biology,” says Sek Kathiresan, who studies the genetics of heart disease at the Broad Institute in Cambridge, Massachusetts.
The expanded database will, for instance, make it much easier to locate rare genetic mutants whose bodies suggest ideas for new drugs.
Regeneron Pharmaceuticals, the company leading the sequencing consortium, based an anti-heart-attack drug, Praluent, on the 14-year-old chance discovery that certain unusual people who lack a working version of one gene, PCSK9, have incredibly low cholesterol.
That kind of serendipity is being made commonplace by methods that automatically scour data on hundreds of thousands of people. “It takes me and my browser 30 seconds to rediscover PCSK9,” says Regeneron CSO George D. Yancopoulos. “And I think there are thousands of those in the genome.”
The gene decoding effort will occur at Regeneron’s sequencing facility in Tarrytown, New York. Regeneron will be joined by five other drug firms—AbbVie, Alnylam, AstraZeneca, Biogen, and Pfizer—that will each contribute $10 million for the effort. The companies will have private access to the newly created data for 12 months, but then it will become public.
“There is so much information here, there is no one company that can take advantage of all of it,” says Yancopoulos. “We think of this as adding accelerant to science.”
The joint project is not only big news for biomedical science, however. It also widens an already yawning gap between Britain and the U.S., whose own large population study is far behind. According to the National Institutes of Health, the million-person “AllofUs” study has recruited 10,000 people but has not yet sequenced anyone’s DNA.
A spokesperson for the NIH said the $4.3 billion program is “on target” with its goals and plans a national launch this spring.
Yancopoulos calls the slow start by the U.S. “a national embarrassment.” The U.K. data trove is set to dominate “for the foreseeable future, the next five to 10 years,” he says. “It’s going to be the best resource. It’s the first place people will go.”

Wattup Wireless charging technology gets FCC Certification

Energous Gets FCC Certification for WattUp Wireless Charging Technology

After three years of debut of Energous’ wireless “power at a distance” charging system, it has now approved by the Federal Communications commission (FCC). FCC has approved this new type of charger, Wattup Mid Field transmitter, for the first time.

This technology is much more advance than the previous wireless charging technologies because this will charge up batteries from as far as three feet away. And with this, we enter a complete new era of wireless charging of devices.

It is able to charge battery-operated devices like phone, tablets, smart speakers, smart watches, fitness trackers etc. using a technique that Energous compares to Wi-Fi, as long as the battery-operated device has the company’s receivers. Wattup has a transmitter which emits energy via a radio frequency signal. It is being delivered by custom chips and miniature antenna arrays. And after the transmission, device having the Wattup receiver converts the RF signal into battery power.

Energous claims its product being the only one which can charge using both wired as well as wireless charging technology. It can even charge more than one devices simultaneously and will keep on charging until they are charged to a certain point.

Wattup was released in 2015 at CES and rumors were there for Wattup collaborating for wireless charging of iPhone X in 2017 but Apple went ahead with inductive wireless charging on iPhone X and iPhone 8 this year. It is being speculated that Apple may work with Energous on implementing this technology on future iPhones or at least make a Wattup iPhone accessory certified by MFi.

Energous will be displaying this wireless charging technology at the Consumer Electronic show at Las vegas next  month from 9th-12th January.

Future iPhones could be wirelessly charged from longer distance

New Apple patent application hints at long-range wireless ranging

If you’re an iPhone user or planning to become one, this is a great news for you. A patent product with a new technology was filed by Apple which suggests wireless charging of future iPhones from across the room.

According to the officially published notes by US Patent & Trademark Office (USPTO), this new product will be “configured to wireless transmit power over the wireless power transfer link.” It means that this new system may charge multiple devices simultaneously with both wired as well as wireless connections.

Apple is currently focusing on short range wireless charging only because long range wireless charging is not feasible. Because as the distance increases from the charger, power decreases rapidly and there’s a limited amount of power which can be transmitted to single device.

This RF-based short range wireless charger would allow users to set up their wireless charging devices in a certain order. This method will link a single power adapter to various electronic devices in its proximity.

Here is an excerpt of the patent filings’ summary:

A system having a power adapter may supply power to electronic devices. Electronic devices with battery could be charged such as smartphones, laptops, tablets, PCs, smartwatches, fitness bands etc. Charging to the electronic devices would occur both using wired as well as wireless medium. The system with an online user account, will create a communication network and would be connected to the charging devices in its proximity. The system will save information from user such as battery state, priority of charging devices, usage history, calendar and few other information. And this system will transfer different amount of power to different devices connected to it using an optimum power transfer strategy.

Patents doesn’t necessarily mean something solid. Hence, nothing further can be suggested. But this definitely tells that Apple is working hard on creating a wireless charging device. Let’s see when Apple confirms this news officially.

Japanese developer discovers a way to erase your face using iPhone X

This Japanese developer uses an iPhone X to make his face disappear

If Harry Potter’s invisibility cloak had fascinated you, then Apple iPhone X’s Face ID camera might have something to interest you.

In a tweet first spotted by Design Taxi, Kazuya Nosiro, a Japanese app developer and CEO of game development company ViRD, released a 10-second video clip, that shows his face completely camouflaged, except for his eyes and mouth, into his surroundings in a trick of ‘optical camouflage’.

The app (is still a work-in-progress) that Noshiro used to make the trick possible was made on the game development platform ‘Unity’. To pre-record the background of the room, Noshiro first used a fixed camera. Then, he used the app to camouflage his face and replaced it with the background image using iPhone X’s TrueDepth camera face detection capability and Apple’s ARKit development platform. However, the eyes, the hair, and rest of the body were still visible.

“If you want to make your face transparent, we’re recruiting,” Noshiro joked.

Check out the video below to see it for yourself:

The app is likely to be exclusive to owners of Apple’s flagship device. However, it is not known when this app will be released and what the app may be actually used for.

10 Best Websites To Download Paid PC Games For Free And Legally in 2018

In desperate times you might find yourself looking for new games. But good games come at a cost. What if I told you that you could download paid PC games for free and legally? Now, you can either take the legal way or the illegal way to download games. But, taking the illegal way is dishonoring all the hard work the game developers did to create a masterpiece out of their imagination. So, how to get free pc games without paying a penny for premium content? There are a number of websites that giveaway paid games for free. Visit these sites often if you want free games. Here, we have prepared a list of the 10 best places to grab premium games for free.

10 Websites to Download Paid PC Games Free And Legally in 2018

1. Origin On the house

Every now and then, Origin gives a premium game free of cost on this website. They are not trials or demos but full versions and expansions. Games such as Mass Effect 2, and Battlefield 3 were hosted on this site, so keep checking it often to download paid PC games for free.

2. IGN Beta Giveaway

IGN Beta Giveaway hosts premium games and lets you download paid PC games for free. If you are a prime member then redeem your beta code to get full access to paid games. At the time of writing this article, they are giving away Destiny 2. Isn’t that cool?

3. Reddit’s freegames subreddit

While Reddit has several subreddits dedicated to free game giveaways, r/freegames is the most noteworthy. Users submit links to full games and giveaways on this subreddit. So, bookmark this page for getting your hands on some freebies.

4. Steamgifts

You will find a huge community of gamers here. You can learn how to become a member, how to sponsor giveaways, or how to use Steamgifts through their FAQ section.

The link to your steam account is needed so that the community members can find your profile in case you won something or if you need to contact people who won a game of your giveaway. It also makes it impossible for people to try to win games that they have already redeemed on Steam. Hence, the user base is protected, and it’s harder for scammers to use the site.

Also Read: 10 Amazing Linux Terminal Based Games That You Must Know

5. SteamCompanion

This website is similar to Steamgifts and works the same way to help you download paid PC games for free. It allows people to host Steam giveaways and the possibility to play and win Steam games. You will need to link your steam account to SteamCompanion. They have a Steam calculator that shows you total worth of your Steam games and time spent on them.

6. Green Man Gaming

Green Man Gaming is an online video game retailer based in the United Kingdom and has a catalog of over 5200 games from more than 450 game publishers. It has won more than 25 awards, latest being the MCV Awards 2017.

Green Man Gaming has a monthly giveaway for paid games. They send you a Steam key, and if you already own the game, it can be given to someone else.

7. GOG

GOG is a digital distribution platform service for video games and films. It is operated by GOG Limited and is a wholly owned subsidiary of CD Projekt. On 26 March 2009, GOG.com signed a deal with Ubisoft which allows them to publish games from Ubisoft’s back catalog.

They give away at least two or three premium games per year and the give away last for around 48 hours.

8. Humble Bundle

It has a great collection of games, and a portion of the price goes towards charity while the rest is split between the game developers. They organize Steam key giveaway and also has a subreddit for requests and giveaways to help you get premium games for free and legally.

9. DLH.net

DLH.Net has been around for more than 20 years now. Under the motto “By gamers, for gamers,” a large community has developed. DLH.Net got its name from “Dirty Little Helper” because it used to post game cheats and tricks. They give away free steam game keys from time to time and also provide free Steam keys for new users who sign up on their website. So, don’t forget to check out this community to get paid PC games for free and legally.

10. Steam

Steam communities have several groups that give away paid PC games free of cost. Free Games GiveAways has more than 13000 users and give away legal games, Steam game keys, Steam gifts, Steam in-game items or Steam game cards for free. Game GiveAway Group is one of the biggest active community who has given away more than 100,000 games.

Apple co-founder Steve Wozniak launches his own online technical university ‘Woz U’

Steve Wozniak announces tech education platform Woz U

Steve WozniaK – the man who co-founded Apple alongside the late Steve Jobs is launching a new portal Woz U and thereby entering the education sector. The portal is designed to promote technology jobs and provide skills to enter the tech industry .The institute will be headquartered in Scottsdale, Arizona.

Woz U is part of the private & for-profit Southern Careers Institute which operates 7 campuses in Texas alongside an online school (so do not expect everything on the portal to be free). Yet, Steve Wozniak plans to partner with other colleges and institutes as they develop and grow. The plans are to expand the initiative to include as much as 30 physical locations globally with courses ranging from software development to IT to mobile app development to cyber security.

“OUR GOAL IS TO EDUCATE AND TRAIN PEOPLE IN EMPLOYABLE DIGITAL SKILLS WITHOUT PUTTING THEM INTO YEARS OF DEBT,” WOZNIAK, WHO ALSO WORKED AS AN ELEMENTARY SCHOOL TEACHER, SAID IN A STATEMENT. “PEOPLE OFTEN ARE AFRAID TO CHOOSE A TECHNOLOGY-BASED CAREER BECAUSE THEY THINK THEY CAN’T DO IT. I KNOW THEY CAN, AND I WANT TO SHOW THEM HOW.”

Tech companies interested in using the tools & resources provided by Woz U to train and recruit employees also have access. The platform will be available to students K-12 through partnerships with school districts as well. Further in the future, Woz plans to offer one-to-one instructions to students and also create its own accelerator program for prospective startup founders. The objective is to generate and increase interest in STEAM fields/ careers which include Science, Technology, Engineering, Arts & Mathematics. There will also be a focus on Arts possibly as a nod to Wozniak’s role at Apple and Steve Job’s lifelong mission to blend technology with humanities.

“MY ENTIRE LIFE I HAVE WORKED TO BUILD, DEVELOP, AND CREATE A BETTER WORLD THROUGH TECHNOLOGY AND I HAVE ALWAYS RESPECTED EDUCATION. NOW IS THE TIME FOR WOZ U, AND WE ARE ONLY GETTING STARTED.”

No pricing details have been revealed so far, although a mobile app is already availabe with some introductory courses. You can also enroll yourself with Woz U starting today , though do not expect much other than providing your personal information.

Recover Your Lost Data Using MobiKin Doctor for Android

While Apple keeps getting the majority of profit share of the smartphone market, Android smartphones continue to enjoy an unparalleled popularity among the masses due to their user-friendliness and cheaper price. For about half the price of an iPhone, you can grab an Android flagship and enjoy top-notch specifications.

Due to this popularity, Android has become one of most popular operating systems in the world. There are numerous tools available on the web that promise to provide the best phone management but only a few of them turn out to be useful; such is the case of recovery tools that help you get your lost data back. The lost data being talked about here could be due to a faulty upgrade, malware, physical damage, water damage, etc. To help you out, here I’m going to tell you about MobiKin Doctor for Android.

This tool helps you in the time of emergency when you need to get back important documents. Mentioned below are seven types of data that can be recovered by this tool:

  • Contacts
  • Messages
  • Call Logs
  • Photos
  • Videos
  • Audio
  • Documents

Talking about the supported devices, MobiKin lets you recover data from all popular brands like Samsung, Motorola, HTC, LG, Google, Sony, Huawei, Asus, etc. The same is true for Android versions. The tool performs a deep scanning of the device’s internal memory and SD card for performing the recovery. You have the option to get back contacts, call logs, and SMS in HTML format. One should note that root access is needed for performing these actions. In case of files like media and document, root access isn’t required and the files are preserved in original format.

Use Mobikin Doctor for Android for recovery

You can go ahead and download Mobikin Doctor for Android by clicking on the download button given below. The setup isn’t large in size and it just takes a few moments to complete the download. After that, perform the installation like any other regular software and open the program.

MobiKin Doctor For Android

To start the recovery process, you need to first connect your Android device to your computer using the USB cable. Before attempting to connect, make sure that USB debugging is enabled on your phone. Once you’ve done that, connect your device and you should be able to see the device information in the program window. In my case, you can see the device name ASUS_Z012D, model number, serial number, charging level, etc.

mobikin android recovery add phone

Below the device information, you’ll see different types of data listed that you can recover. By default, all types of data is selected. You need to choose as per your requirement and proceed with the recovery process.

mobikin android recovery 1

After selecting the type of data that needs to be recovered, simply press the Next button. It’ll start the scanning process to find out which files have been deleted and which can be recovered. Depending on the amount of stored data on your Android smartphone and the number of deleted files, the time of scanning might vary.

Once the scan is completed, all the deleted files are listed in a new window. As you’re seeing in the picture shown below, the list of file types is in the left pane. Once you click on a file type, data of the same is displayed in the right. You also get to see the preview of the file, which helps in making the right choice during the recovery process.

mobikin android recovery 2

After analyzing the deleted files and choosing the ones that need to be recovered, you need to proceed with the Recover option. It’ll prompt you to specify the recovery location on your computer. After selecting a location, you can complete the process and get back your precious data.

mobikin android recovery 3

Apart from getting back the lost data from the Android internal memory, you can also do the same for SD card. To do so, you need to select the Android SD Card Recovery option from the top tap in the application and proceed with the options.

mobikin android recovery sd card

Overall, if you’re looking for a simple way to recover your deleted data like messages, contacts, photos, etc., from your Android device, you can use Mobikin Doctor for Android. You can visit their website to get the free trial or buy the full version for $49.95.

Scientists suggest new theory behind the mystery of the Bermuda Triangle

The mystery of the Bermuda Triangle may finally have been solved by a group of satellite meteorologists.

For decades, a series of disappearances within the 500,000km square area between Miami, Puerto Rico and Bermuda has remained unexplained and dismissed as coincidental by many.

The triangle is said to be responsible for the loss of at least 1,000 lives along with some 75 planes and hundreds of ships within the past 100 years.

Scientists have now claimed that hexagonal clouds creating “air-bombs” with winds of up to 170mph could be responsible for hundreds of unsolved incidents at sea.

The storms are said to be so powerful that ships and planes can be plunged into the sea in an instant.

Researchers also noted that large-scale clouds were appearing over the western tip of the island of Bermuda, ranging from 20 to 55 miles wide.

Dr Steve Miller, a satellite meteorologist at Colorado State University, told the Science Channel’s What on Earth programme: “You don’t typically see straight edges with clouds.

“Most of the time, clouds are random in their distribution.“

Using radar satellites to measure what was happening underneath the unusual clouds, the research group found sea level winds were also reaching dangerously high speeds, creating waves as high as 45ft as a result.

Metereologist Randy Cerveny said the hexagonal shapes over the ocean “are in essence air bombs”.

“They are formed by what are called microbursts and they’re blasts of air that come down out of the bottom of a cloud and then hit the ocean,” he explained.

These environmental factors “create waves that can sometimes be massive in size as they start to interact with each other.”

Claims of unusual and ‘paranormal’ occurances were made as far back as 1492, whoever, when Christopher Columbus reported seeing strange lights and compass readings.

An average of four planes and 20 ships are said to go missing in the area each year.

Flying cars could hit the skies in 2019 after Volvo’s parent company Geely buys ‘street-legal plane’ startup Terrafugia

Geely announced this week that it has acquired Terrafugia’s operations and assets in their entirety.

Mr Li Shufu, founder and chairman of Geely, said: ‘The team at Terrafugia have been at the forefront of believing in and realizing the vision for a flying car and creating the ultimate mobility solution.

‘This is a tremendously exciting sector and we believe that Terrafugia is ideally positioned to change mobility as we currently understand it and herald the development of a new industry in doing so.

‘Our investment in the company reflects our shared belief in their vision and we are committed to extending our full support to Terrafugia, leveraging the synergies provided by our international operations and track record of innovation, to make the flying car a reality.’

Since it was formed in 2006, Terrafugia has been working on flying cars, and has since developed a number of working prototypes.

The firm aims to deliver its first flying car to the market in 2019, with the world’s first vertical take-off and landing (VTOL) flying car being made available by 2023.

Terrafugia’s Transition was recently granted an exemption by the FAA, allowing it to be classified as a ‘light-sport’ craft.

The aircraft has fold-out wings that weigh roughly 1,300 pounds, and have fixed landing gear.

They seat a maximum of two people, including the pilot.

To operate them, one must have a sport pilot certificate, which requires just 20 hours of training.

The craft reaches a cruise speed of 100 mph, and can achieve a range of 400 miles.

And, it can fly to a maximum altitude of 10,000 feet.

The firm’s newer design, the concept TF-X, has fold-out wings with twin electric motors attached to each end, and is expected to cost £183,000 ($261,000).

THE TF-X: KEY SPECIFICATIONS

The vehicle will have a cruising speed of 200 mph (322 km/h), along with a 500-mile (805 km) flight range.

TF-X will have fold-out wings with twin electric motors attached to each end.

These motors allow the TF-X to move from a vertical to a horizontal position, and will be powered by a 300 hp engine.

The planned four-person TF-X will be semi-autonmous and use computer-controlled so that passengers can simply type in a destination before taking off.

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TF-X vehicles will be capable of automatically avoiding other air traffic, bad weather, and restricted and tower-controlled airspace.

The vehicle will be able to recharge its batteries either from its engine or by plugging in to electric car charging stations.

It is expected to cost £183,000 ($261,000).

These motors allow the TF-X to move from a vertical to a horizontal position, and will be powered by a 300 horsepower engine.

Thrust will be provided by a ducted fan, and the vehicle will have a cruising speed of 200 mph (322 km/h), along with a 500-mile (805 km) flight range.

Chris Jaran, CEO of Terrafugia, said: ‘After working in the helicopter industry for over 30 years, and the aviation industry in China for 17 years, Terrafugia presents a unique opportunity to be at the forefront of a fledgling but enormously exciting industry.’

How To Free Up Disk Space In Windows 10 Using OneDrive Files On-Demand?

The Windows 10 Fall Creators Update arrived with many handy features. And one FCU feature can help you free up disk space on your hard drive using the power of the cloud. It’s known as OneDrive Files On-Demand.

What is OneDrive Files On-Demand?

If you’re running the Fall Creators Update on your Windows 10 PC, you can edit your files – stored in your OneDrive cloud storage – on your computer without downloading them permanently. It can be done using OneDrive Files On-Demand. This facility can help you free up disk space on your computer which you can use to store other things if you want.

The files on your OneDrive which you have marked “online-only” are downloaded when you want to edit them. For instance, when you want to make changes to your Powerpoint presentation. After you have done the editing, the version of the file on OneDrive is replaced with the new one.

How to use OneDrive Files On Demand?

You should set up OneDrive on your device in advance to turn on the feature. To sign-in, open the OneDrive app from the Start Menu and follow the setup.

onedrive setup screen

Next, follow the steps mentioned below to enable Files On-Demand on Windows 10 FCU:

  1. Right-click the OneDrive icon in the Notifications area.
  2. Go to Settings from the drop-down menu.
    turn on onedrive files on-demand windows 10
  3. Under the Settings tab, tick the checkbox that says “Save space and download files as you use them” to turn on the feature and free up disk space on your machine.
    open one drive settings
  4. Click Ok to save and continue.

After you enable the feature, you can see it working in File Explorer > OneDrive folder. A cloud status icon gets attached to the files and folders which are online-only. You can disable the on-demand feature by following the same steps.

To mark a file or folder as online-only, go the OneDrive folder, right-click the file and click “Free Up Space” in the context menu.

onedrive files on-demand free up space

 

The files you’ve created online or on other devices are online-only by default. If you want a file to be available offline on your current device, click “Always keep on this device” option.

onedrive files on-demand status

One thing to keep in mind is that turning on OneDrive Files On-Demand for one Windows 10 PC won’t enable it across all of your devices. These settings are tied individually to your devices.

Also, I won’t recommend you to use the Files on-demand feature if your internet bandwidth is limited as any change you make to the online-only files would cost you valuable data. As an alternative, you can check out Google’s Backup & Sync tool which automatically syncs the folders on your hard drive.